
Keep in mind if you die in here, you will not be able to respawn even if you have an item that offers that ability. You cannot deal damage to this enemy, so all you can do is run. Find the key piece at the end of the path and prepare to run back the way you came while being chased by a dark mysterious monster resembling your mother. Get in the Minecart and you’ll be taken to a special area where you will lose all of your abilities and stats. The third button will always be in the room with the Minecart which is exactly where you want to go. In order to find the key piece, you will first need to find three yellow buttons scattered throughout the map.

In order to get to Corpse II, you’ll first need to reach Corpse which requires a special key to access.

However, getting to Corpse II requires a pretty specific sequence of events. In short, in order to unlock Jacob & Esau, you need to beat the new ending boss, Mother, who can be found on the floor Corpse II. Unlocking Jacob & Esau in Binding of Isaac Repentance Unlike Bethany, the other new character added in the Binding of Isaac: Repentance who has a fairly straightforward unlock path, unlocking Jacob & Esau is a bit more complicated.
